Ontology highlight
ABSTRACT:
SUBMITTER: Jia M
PROVIDER: S-EPMC6368864 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Jia Min M Liu Xiayan X Xue Hui H Wu Yue Y Shi Lin L Wang Rui R Chen Yu Y Xu Ni N Zhao Jun J Shao Jingxia J Qi Yafei Y An Lijun L Sheen Jen J Yu Fei F
Nature plants 20190121 2
Protein homeostasis is essential for cellular functions and longevity, and the loss of proteostasis is one of the hallmarks of senescence. Autophagy is an evolutionarily conserved cellular degradation pathway that is critical for the maintenance of proteostasis. Paradoxically, autophagy deficiency leads to accelerated protein loss by unknown mechanisms. We discover that the ABNORMAL SHOOT3 (ABS3) subfamily of multidrug and toxic compound extrusion transporters promote senescence under natural an ...[more]