Ontology highlight
ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC6279399 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Chen Yongzhi Y Sharma Shruti S Assis Patricia A PA Jiang Zhaozhao Z Elling Roland R Olive Andrew J AJ Hang Saiyu S Bernier Jennifer J Huh Jun R JR Sassetti Christopher M CM Knipe David M DM Gazzinelli Ricardo T RT Fitzgerald Katherine A KA
The Journal of experimental medicine 20181115 12
An inducible program of inflammatory gene expression is a hallmark of antimicrobial defenses. Recently, cellular nucleic acid-binding protein (CNBP) was identified as a regulator of nuclear factor-kappaB (NF-κB)-dependent proinflammatory cytokine gene expression. Here, we generated mice lacking CNBP and found that CNBP regulates a very restricted gene signature that includes IL-12β. CNBP resides in the cytosol of macrophages and translocates to the nucleus in response to diverse microbial pathog ...[more]