Ontology highlight
ABSTRACT:
SUBMITTER: Bowry A
PROVIDER: S-EPMC6280123 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Bowry Akhil A Piberger Ann Liza AL Rojas Patricia P Saponaro Marco M Petermann Eva E
Cell reports 20181101 8
BET bromodomain proteins are required for oncogenic transcription activities, and BET inhibitors have been rapidly advanced into clinical trials. Understanding the effects of BET inhibition on processes such as DNA replication will be important for future clinical applications. Here, we show that BET inhibition, and specifically inhibition of BRD4, causes replication stress through a rapid overall increase in RNA synthesis. We provide evidence that BET inhibition acts by releasing P-TEFb from it ...[more]