Ontology highlight
ABSTRACT:
SUBMITTER: Urban V
PROVIDER: S-EPMC4987291 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Urban Vaclav V Dobrovolna Jana J Hühn Daniela D Fryzelkova Jana J Bartek Jiri J Janscak Pavel P
The Journal of cell biology 20160808 4
Collisions between replication and transcription machineries represent a significant source of genomic instability. RECQ5 DNA helicase binds to RNA-polymerase (RNAP) II during transcription elongation and suppresses transcription-associated genomic instability. Here, we show that RECQ5 also associates with RNAPI and enforces the stability of ribosomal DNA arrays. We demonstrate that RECQ5 associates with transcription complexes in DNA replication foci and counteracts replication fork stalling in ...[more]