Heart Regeneration in the Mexican Cavefish.
Ontology highlight
ABSTRACT:
SUBMITTER: Stockdale WT
PROVIDER: S-EPMC6280125 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
Heart Regeneration in the Mexican Cavefish.
Stockdale William T WT Lemieux Madeleine E ME Killen Abigail C AC Zhao Juanjuan J Hu Zhilian Z Riepsaame Joey J Hamilton Noémie N Kudoh Tetsuhiro T Riley Paul R PR van Aerle Ronny R Yamamoto Yoshiyuki Y Mommersteeg Mathilda T M MTM
Cell reports 20181101 8
Although Astyanax mexicanus surface fish regenerate their hearts after injury, their Pachón cave-dwelling counterparts cannot and, instead, form a permanent fibrotic scar, similar to the human heart. Myocardial proliferation peaks at similar levels in both surface fish and Pachón 1 week after injury. However, in Pachón, this peak coincides with a strong scarring and immune response, and ultimately, cavefish cardiomyocytes fail to replace the scar. We identified lrrc10 to be upregulated in surfac ...[more]
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