Immune Checkpoint PD-1/PD-L1: Is There Life Beyond Antibodies?
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ABSTRACT:
SUBMITTER: Konstantinidou M
PROVIDER: S-EPMC6280658 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Publications
Immune Checkpoint PD-1/PD-L1: Is There Life Beyond Antibodies?
Konstantinidou Markella M Zarganes-Tzitzikas Tryfon T Magiera-Mularz Katarzyna K Holak Tad A TA Dömling Alexander A
Angewandte Chemie (International ed. in English) 20180223 18
The PD-1/PD-L1 interaction has emerged as a significant target in cancer immunotherapy. Current medications include monoclonal antibodies, which have shown impressive clinical results in the treatment of several types of tumors. The cocrystal structure of human PD-1 and PD-L1 is expected to be a valuable starting point for the design of novel inhibitors, along with the recent crystal structures with monoclonal antibodies, small molecules, and macrocycles. ...[more]
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