Ontology highlight
ABSTRACT:
SUBMITTER: Tyner JW
PROVIDER: S-EPMC6280667 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Nature 20181017 7728
The implementation of targeted therapies for acute myeloid leukaemia (AML) has been challenging because of the complex mutational patterns within and across patients as well as a dearth of pharmacologic agents for most mutational events. Here we report initial findings from the Beat AML programme on a cohort of 672 tumour specimens collected from 562 patients. We assessed these specimens using whole-exome sequencing, RNA sequencing and analyses of ex vivo drug sensitivity. Our data reveal mutati ...[more]