Ontology highlight
ABSTRACT:
SUBMITTER: Young LC
PROVIDER: S-EPMC6280710 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Young Lucy C LC Rodriguez-Viciana Pablo P
Cold Spring Harbor perspectives in medicine 20181203 12
MRAS is the closest relative to the classical RAS oncoproteins and shares most regulatory and effector interactions. However, it also has unique functions, including its ability to function as a phosphatase regulatory subunit when in complex with SHOC2 and protein phosphatase 1 (PP1). This phosphatase complex regulates a crucial step in the activation cycle of RAF kinases and provides a key coordinate input required for efficient ERK pathway activation and transformation by RAS. MRAS mutations r ...[more]