Dataset Information

Circulating cotinine concentrations and lung cancer risk in the Lung Cancer Cohort Consortium (LC3).

ABSTRACT:

Background

Self-reported smoking is the principal measure used to assess lung cancer risk in epidemiological studies. We evaluated if circulating cotinine-a nicotine metabolite and biomarker of recent tobacco exposure-provides additional information on lung cancer risk.

Methods

The study was conducted in the Lung Cancer Cohort Consortium (LC3) involving 20 prospective cohort studies. Pre-diagnostic serum cotinine concentrations were measured in one laboratory on 5364 lung cancer cases and 5364 individually matched controls. We used conditional logistic regression to evaluate the association between circulating cotinine and lung cancer, and assessed if cotinine provided additional risk-discriminative information compared with self-reported smoking (smoking status, smoking intensity, smoking duration), using receiver-operating characteristic (ROC) curve analysis.

Results

We observed a strong positive association between cotinine and lung cancer risk for current smokers [odds ratio (OR ) per 500 nmol/L increase in cotinine (OR500): 1.39, 95% confidence interval (CI): 1.32-1.47]. Cotinine concentrations consistent with active smoking (≥115 nmol/L) were common in former smokers (cases: 14.6%; controls: 9.2%) and rare in never smokers (cases: 2.7%; controls: 0.8%). Former and never smokers with cotinine concentrations indicative of active smoking (≥115 nmol/L) also showed increased lung cancer risk. For current smokers, the risk-discriminative performance of cotinine combined with self-reported smoking (AUCintegrated: 0.69, 95% CI: 0.68-0.71) yielded a small improvement over self-reported smoking alone (AUCsmoke: 0.66, 95% CI: 0.64-0.68) (P = 1.5x10-9).

Conclusions

Circulating cotinine concentrations are consistently associated with lung cancer risk for current smokers and provide additional risk-discriminative information compared with self-report smoking alone.

SUBMITTER: Larose TL

PROVIDER: S-EPMC6280953 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Publications

Circulating cotinine concentrations and lung cancer risk in the Lung Cancer Cohort Consortium (LC3).

Larose Tricia L TL Guida Florence F Fanidi Anouar A Langhammer Arnulf A Kveem Kristian K Stevens Victoria L VL Jacobs Eric J EJ Smith-Warner Stephanie A SA Giovannucci Edward E Albanes Demetrius D Weinstein Stephanie J SJ Freedman Neal D ND Prentice Ross R Pettinger Mary M Thomson Cynthia A CA Cai Qiuyin Q Wu Jie J Blot William J WJ Arslan Alan A AA Zeleniuch-Jacquotte Anne A Le Marchand Loic L Wilkens Lynne R LR Haiman Christopher A CA Zhang Xuehong X Stampfer Meir J MJ Hodge Allison M AM Giles Graham G GG Severi Gianluca G Johansson Mikael M Grankvist Kjell K Wang Renwei R Yuan Jian-Min JM Gao Yu-Tang YT Koh Woon-Puay WP Shu Xiao-Ou XO Zheng Wei W Xiang Yong-Bing YB Li Honglan H Lan Qing Q Visvanathan Kala K Hoffman Bolton Judith J Ueland Per Magne PM Midttun Øivind Ø Caporaso Neil N Purdue Mark M Sesso Howard D HD Buring Julie E JE Lee I-Min IM Gaziano J Michael JM Manjer Jonas J Brunnström Hans H Brennan Paul P Johansson Mattias M

International journal of epidemiology 20181201 6

<h4>Background</h4>Self-reported smoking is the principal measure used to assess lung cancer risk in epidemiological studies. We evaluated if circulating cotinine-a nicotine metabolite and biomarker of recent tobacco exposure-provides additional information on lung cancer risk.<h4>Methods</h4>The study was conducted in the Lung Cancer Cohort Consortium (LC3) involving 20 prospective cohort studies. Pre-diagnostic serum cotinine concentrations were measured in one laboratory on 5364 lung cancer c ...[more]

PMID: 29901778

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Dataset Information

Circulating cotinine concentrations and lung cancer risk in the Lung Cancer Cohort Consortium (LC3).

Background

Methods

Results

Conclusions

Publications

Circulating cotinine concentrations and lung cancer risk in the Lung Cancer Cohort Consortium (LC3).

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