A decrease in vitamin D levels is associated with methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia.

ABSTRACT:

Purpose

Children with acute lymphoblastic leukemia (ALL) are at increased risk of vitamin D deficiency, which might make them more susceptible to developing adverse events. Previous studies showed that low vitamin D levels were associated with an increased inflammatory mucosal state and impaired mucosal tissue barriers. We examined the prevalence of vitamin D deficiency and studied the association between vitamin D levels and methotrexate (MTX)-induced oral mucositis in pediatric ALL.

Methods

We assessed 25-hydroxyvitamin D (25(OH)D₃) and 24,25-dihydroxyvitamin D (24,25(OH)₂D₃) levels in 99 children with ALL before the start of 4 × 5 g/m² high-dose methotrexate (HD-MTX) (T0) and in 81/99 children after discontinuation of HD-MTX (T1

SUBMITTER: Oosterom N 

PROVIDER: S-EPMC6280960 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature