Immunogenicity and safety of a tetanus-diphtheria vaccine and a 13-valent pneumococcal conjugate vaccine after concomitant vaccination in???50-year-old adults.
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ABSTRACT: BACKGROUND:When two or more vaccines are administered concurrently, there is concern about safety and immunogenicity from vaccine interaction. METHODS:Subjects aged ?50 years were randomized 1:1:1 to receive tetanus-diphtheria (Td)?+?13-valent pneumococcal conjugate vaccine (PCV13; Group 1), PCV13 alone (Group 2), or Td alone (Group 3). After single or concomitant vaccination, enzyme-linked immunosorbent assay and opsonophagocytic assay (OPA) were performed to compare immunogenicity for Td and PCV13, respectively. RESULTS:A total of 448 subjects were available for the assessment. After concomitant administration, the non-inferiority criteria of geometric mean titer (GMT) ratios were met for tetanus, diphtheria, and all four pneumococcal serotypes (1, 5, 18C, and 19A). However, subjects in Group 3 (Td alone) were more likely to have a high IgG anti-tetanus antibody titer (? 0.5 U/mL) than those in Group 1 (Td?+?PCV13) (p?
SUBMITTER: Song JY
PROVIDER: S-EPMC6282243 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
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