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Immunogenicity and safety of a tetanus-diphtheria vaccine and a 13-valent pneumococcal conjugate vaccine after concomitant vaccination in???50-year-old adults.

ABSTRACT: BACKGROUND:When two or more vaccines are administered concurrently, there is concern about safety and immunogenicity from vaccine interaction. METHODS:Subjects aged ?50 years were randomized 1:1:1 to receive tetanus-diphtheria (Td)?+?13-valent pneumococcal conjugate vaccine (PCV13; Group 1), PCV13 alone (Group 2), or Td alone (Group 3). After single or concomitant vaccination, enzyme-linked immunosorbent assay and opsonophagocytic assay (OPA) were performed to compare immunogenicity for Td and PCV13, respectively. RESULTS:A total of 448 subjects were available for the assessment. After concomitant administration, the non-inferiority criteria of geometric mean titer (GMT) ratios were met for tetanus, diphtheria, and all four pneumococcal serotypes (1, 5, 18C, and 19A). However, subjects in Group 3 (Td alone) were more likely to have a high IgG anti-tetanus antibody titer (? 0.5 U/mL) than those in Group 1 (Td?+?PCV13) (p?

SUBMITTER: Song JY 

PROVIDER: S-EPMC6282243 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Immunogenicity and safety of a tetanus-diphtheria vaccine and a 13-valent pneumococcal conjugate vaccine after concomitant vaccination in ≥ 50-year-old adults.

Song Joon Young JY   Cheong Hee Jin HJ   Noh Ji Yun JY   Choi Min Joo MJ   Yoon Jin Gu JG   Lee Saem Na SN   Kang Seong Hui SH   Jeong Eun Joo EJ   Jo Yu Mi YM   Kim Woo Joo WJ  

BMC infectious diseases 20181205 1

<h4>Background</h4>When two or more vaccines are administered concurrently, there is concern about safety and immunogenicity from vaccine interaction.<h4>Methods</h4>Subjects aged ≥50 years were randomized 1:1:1 to receive tetanus-diphtheria (Td) + 13-valent pneumococcal conjugate vaccine (PCV13; Group 1), PCV13 alone (Group 2), or Td alone (Group 3). After single or concomitant vaccination, enzyme-linked immunosorbent assay and opsonophagocytic assay (OPA) were performed to compare immunogenici  ...[more]

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