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Solid-Phase Conversion of Four Stereoisomers into a Single Enantiomer.

ABSTRACT: Viedma ripening is an emerging method for the solid-phase deracemization of mixtures of enantiomers. Up to now, the scope of the method has remained limited to molecules with a single stereocenter. We show here that this method can be extended to obtain a single enantiomer from a mixture of stereoisomers with two different stereocenters. In addition, we show that by using tailor-made chiral additives, the conversion time can be reduced by a factor of 100.

SUBMITTER: Engwerda AHJ

PROVIDER: S-EPMC6282611 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Solid-Phase Conversion of Four Stereoisomers into a Single Enantiomer.

Engwerda Anthonius H J AHJ Mertens Johannes C J JCJ Tinnemans Paul P Meekes Hugo H Rutjes Floris P J T FPJT Vlieg Elias E

Angewandte Chemie (International ed. in English) 20181019 47

Viedma ripening is an emerging method for the solid-phase deracemization of mixtures of enantiomers. Up to now, the scope of the method has remained limited to molecules with a single stereocenter. We show here that this method can be extended to obtain a single enantiomer from a mixture of stereoisomers with two different stereocenters. In addition, we show that by using tailor-made chiral additives, the conversion time can be reduced by a factor of 100. ...[more]

PMID: 30277304

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