Ontology highlight
ABSTRACT:
SUBMITTER: Ferino A
PROVIDER: S-EPMC6284578 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Ferino Annalisa A Miglietta Giulia G Picco Raffaella R Vogel Stefan S Wengel Jesper J Xodo Luigi E LE
RNA biology 20181011 10
Datasets reporting microRNA expression profiles in normal and cancer cells show that miR-216b is aberrantly downregulated in pancreatic ductal adenocarcinoma (PDAC). We found that KRAS, whose mutant G12D allele drives the pathogenesis of PDAC, is a target of miR-216b. To suppress oncogenic KRAS in PDAC cells, we designed single-stranded (ss) miR-216b mimics with unlocked nucleic acid (UNA) modifications to enhance their nuclease resistance. We prepared variants of ss-miR-216b mimics with and wit ...[more]