Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
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ABSTRACT:
SUBMITTER: Evangelou E
PROVIDER: S-EPMC6284793 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
Evangelou Evangelos E Warren Helen R HR Mosen-Ansorena David D Mifsud Borbala B Pazoki Raha R Gao He H Ntritsos Georgios G Dimou Niki N Cabrera Claudia P CP Karaman Ibrahim I Ng Fu Liang FL Evangelou Marina M Witkowska Katarzyna K Tzanis Evan E Hellwege Jacklyn N JN Giri Ayush A Velez Edwards Digna R DR Sun Yan V YV Cho Kelly K Gaziano J Michael JM Wilson Peter W F PWF Tsao Philip S PS Kovesdy Csaba P CP Esko Tonu T Mägi Reedik R Milani Lili L Almgren Peter P Boutin Thibaud T Debette Stéphanie S Ding Jun J Giulianini Franco F Holliday Elizabeth G EG Jackson Anne U AU Li-Gao Ruifang R Lin Wei-Yu WY Luan Jian'an J Mangino Massimo M Oldmeadow Christopher C Prins Bram Peter BP Qian Yong Y Sargurupremraj Muralidharan M Shah Nabi N Surendran Praveen P Thériault Sébastien S Verweij Niek N Willems Sara M SM Zhao Jing-Hua JH Amouyel Philippe P Connell John J de Mutsert Renée R Doney Alex S F ASF Farrall Martin M Menni Cristina C Morris Andrew D AD Noordam Raymond R Paré Guillaume G Poulter Neil R NR Shields Denis C DC Stanton Alice A Thom Simon S Abecasis Gonçalo G Amin Najaf N Arking Dan E DE Ayers Kristin L KL Barbieri Caterina M CM Batini Chiara C Bis Joshua C JC Blake Tineka T Bochud Murielle M Boehnke Michael M Boerwinkle Eric E Boomsma Dorret I DI Bottinger Erwin P EP Braund Peter S PS Brumat Marco M Campbell Archie A Campbell Harry H Chakravarti Aravinda A Chambers John C JC Chauhan Ganesh G Ciullo Marina M Cocca Massimiliano M Collins Francis F Cordell Heather J HJ Davies Gail G de Borst Martin H MH de Geus Eco J EJ Deary Ian J IJ Deelen Joris J Del Greco M Fabiola F Demirkale Cumhur Yusuf CY Dörr Marcus M Ehret Georg B GB Elosua Roberto R Enroth Stefan S Erzurumluoglu A Mesut AM Ferreira Teresa T Frånberg Mattias M Franco Oscar H OH Gandin Ilaria I Gasparini Paolo P Giedraitis Vilmantas V Gieger Christian C Girotto Giorgia G Goel Anuj A Gow Alan J AJ Gudnason Vilmundur V Guo Xiuqing X Gyllensten Ulf U Hamsten Anders A Harris Tamara B TB Harris Sarah E SE Hartman Catharina A CA Havulinna Aki S AS Hicks Andrew A AA Hofer Edith E Hofman Albert A Hottenga Jouke-Jan JJ Huffman Jennifer E JE Hwang Shih-Jen SJ Ingelsson Erik E James Alan A Jansen Rick R Jarvelin Marjo-Riitta MR Joehanes Roby R Johansson Åsa Å Johnson Andrew D AD Joshi Peter K PK Jousilahti Pekka P Jukema J Wouter JW Jula Antti A Kähönen Mika M Kathiresan Sekar S Keavney Bernard D BD Khaw Kay-Tee KT Knekt Paul P Knight Joanne J Kolcic Ivana I Kooner Jaspal S JS Koskinen Seppo S Kristiansson Kati K Kutalik Zoltan Z Laan Maris M Larson Marty M Launer Lenore J LJ Lehne Benjamin B Lehtimäki Terho T Liewald David C M DCM Lin Li L Lind Lars L Lindgren Cecilia M CM Liu YongMei Y Loos Ruth J F RJF Lopez Lorna M LM Lu Yingchang Y Lyytikäinen Leo-Pekka LP Mahajan Anubha A Mamasoula Chrysovalanto C Marrugat Jaume J Marten Jonathan J Milaneschi Yuri Y Morgan Anna A Morris Andrew P AP Morrison Alanna C AC Munson Peter J PJ Nalls Mike A MA Nandakumar Priyanka P Nelson Christopher P CP Niiranen Teemu T Nolte Ilja M IM Nutile Teresa T Oldehinkel Albertine J AJ Oostra Ben A BA O'Reilly Paul F PF Org Elin E Padmanabhan Sandosh S Palmas Walter W Palotie Aarno A Pattie Alison A Penninx Brenda W J H BWJH Perola Markus M Peters Annette A Polasek Ozren O Pramstaller Peter P PP Nguyen Quang Tri QT Raitakari Olli T OT Ren Meixia M Rettig Rainer R Rice Kenneth K Ridker Paul M PM Ried Janina S JS Riese Harriëtte H Ripatti Samuli S Robino Antonietta A Rose Lynda M LM Rotter Jerome I JI Rudan Igor I Ruggiero Daniela D Saba Yasaman Y Sala Cinzia F CF Salomaa Veikko V Samani Nilesh J NJ Sarin Antti-Pekka AP Schmidt Reinhold R Schmidt Helena H Shrine Nick N Siscovick David D Smith Albert V AV Snieder Harold H Sõber Siim S Sorice Rossella R Starr John M JM Stott David J DJ Strachan David P DP Strawbridge Rona J RJ Sundström Johan J Swertz Morris A MA Taylor Kent D KD Teumer Alexander A Tobin Martin D MD Tomaszewski Maciej M Toniolo Daniela D Traglia Michela M Trompet Stella S Tuomilehto Jaakko J Tzourio Christophe C Uitterlinden André G AG Vaez Ahmad A van der Most Peter J PJ van Duijn Cornelia M CM Vergnaud Anne-Claire AC Verwoert Germaine C GC Vitart Veronique V Völker Uwe U Vollenweider Peter P Vuckovic Dragana D Watkins Hugh H Wild Sarah H SH Willemsen Gonneke G Wilson James F JF Wright Alan F AF Yao Jie J Zemunik Tatijana T Zhang Weihua W Attia John R JR Butterworth Adam S AS Chasman Daniel I DI Conen David D Cucca Francesco F Danesh John J Hayward Caroline C Howson Joanna M M JMM Laakso Markku M Lakatta Edward G EG Langenberg Claudia C Melander Olle O Mook-Kanamori Dennis O DO Palmer Colin N A CNA Risch Lorenz L Scott Robert A RA Scott Rodney J RJ Sever Peter P Spector Tim D TD van der Harst Pim P Wareham Nicholas J NJ Zeggini Eleftheria E Levy Daniel D Munroe Patricia B PB Newton-Cheh Christopher C Brown Morris J MJ Metspalu Andres A Hung Adriana M AM O'Donnell Christopher J CJ Edwards Todd L TL Psaty Bruce M BM Tzoulaki Ioanna I Barnes Michael R MR Wain Louise V LV Elliott Paul P Caulfield Mark J MJ
Nature genetics 20180917 10
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify ...[more]