Ontology highlight
ABSTRACT:
SUBMITTER: Gouveia MH
PROVIDER: S-EPMC7893038 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Gouveia Mateus H MH Bentley Amy R AR Leonard Hampton H Meeks Karlijn A C KAC Ekoru Kenneth K Chen Guanjie G Nalls Michael A MA Simonsick Eleanor M EM Tarazona-Santos Eduardo E Lima-Costa Maria Fernanda MF Adeyemo Adebowale A Shriner Daniel D Rotimi Charles N CN
Scientific reports 20210218 1
Genome-wide association studies (GWAS) have identified thousands of genetic loci associated with cross-sectional blood pressure (BP) traits; however, GWAS based on longitudinal BP have been underexplored. We performed ethnic-specific and trans-ethnic GWAS meta-analysis using longitudinal and cross-sectional BP data of 33,720 individuals from five cohorts in the US and one in Brazil. In addition to identifying several known loci, we identified thirteen novel loci with nine based on longitudinal a ...[more]