PSXII-19 Gene sets and pathways associated with residual feed intake in Angus steers.

ABSTRACT: Abstract Although residual feed intake (RFI) is a moderately heritable trait that can be used as a selection tool, little is known about gene pathways and networks that affect it. Angus steers (n=1,460) from 72 contemporary groups (RFI: -6.44 to 7.52 kg/d) were genotyped with Illumina BovineHD or BovineSNP50 BeadChip assays. Significant SNP (P<0.05), identified by a genome-wide association analysis on RFI, were used as proxies for each of the annotated genes in the UMD3.1 bovine reference genome assembly. A gene set enrichment analysis-SNP was performed to identify gene sets and leading edge genes (LEG) and a network analysis was conducted to identify upstream and master regulators influencing RFI. Three enriched gene sets (normalized enrichment score>3.0) related to energy production and

SUBMITTER: Michal J 

PROVIDER: S-EPMC6285512 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature