Ontology highlight
ABSTRACT:
SUBMITTER: Nicol MQ
PROVIDER: S-EPMC6286381 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Nicol Marlynne Q MQ Campbell Gillian M GM Shaw Darren J DJ Dransfield Ian I Ligertwood Yvonne Y Beard Philippa M PM Nash Anthony A AA Dutia Bernadette M BM
Virology 20181031
IFNγ is a key regulator of inflammatory responses but its role in influenza A virus (IAV) pathogenesis is unclear. Our studies show that infection of mice lacking the IFNγ receptor (IFNγR<sup>-/-</sup>) at a dose which caused severe disease in wild type 129 Sv/Ev (WT) mice resulted in milder clinical symptoms and significantly lower lung virus titers by 6 days post-infection (dpi). Viral spread was reduced in IFNγR<sup>-/-</sup> lungs at 2 and 4 dpi. Levels of inflammatory cytokines and chemokin ...[more]