Ontology highlight
ABSTRACT:
SUBMITTER: Liu MQ
PROVIDER: S-EPMC3338759 | biostudies-other | 2012
REPOSITORIES: biostudies-other
Liu Man-Qing MQ Zhou Dun-Jin DJ Wang Xu X Zhou Wang W Ye Li L Li Jie-Liang JL Wang Yi-Zhong YZ Ho Wen-Zhe WZ
PloS one 20120427 4
<h4>Background</h4>Interferon lambda 3 (IFN-λ3) is a newly identified cytokine with antiviral activity, and its single nucleotide polymorphisms are strongly associated with the treatment effectiveness and development of chronic hepatitis C virus infection. We thus examined the potential of IFN-λ3 to inhibit HIV replication and the possible mechanisms of the anti-HIV action by IFN-λ3 in human macrophages.<h4>Principal findings</h4>Under different conditions (before, during, and after HIV infectio ...[more]