GWAS identifies 14 loci for device-measured physical activity and sleep duration.
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ABSTRACT:
SUBMITTER: Doherty A
PROVIDER: S-EPMC6288145 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
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GWAS identifies 14 loci for device-measured physical activity and sleep duration.
Doherty Aiden A Smith-Byrne Karl K Ferreira Teresa T Holmes Michael V MV Holmes Chris C Pulit Sara L SL Lindgren Cecilia M CM
Nature communications 20181210 1
Physical activity and sleep duration are established risk factors for many diseases, but their aetiology is poorly understood, partly due to relying on self-reported evidence. Here we report a genome-wide association study (GWAS) of device-measured physical activity and sleep duration in 91,105 UK Biobank participants, finding 14 significant loci (7 novel). These loci account for 0.06% of activity and 0.39% of sleep duration variation. Genome-wide estimates of ~ 15% phenotypic variation indicate ...[more]
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