Ontology highlight
ABSTRACT:
SUBMITTER: Fassad MR
PROVIDER: S-EPMC6288320 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Fassad Mahmoud R MR Shoemark Amelia A Legendre Marie M Hirst Robert A RA Koll France F le Borgne Pierrick P Louis Bruno B Daudvohra Farheen F Patel Mitali P MP Thomas Lucie L Dixon Mellisa M Burgoyne Thomas T Hayes Joseph J Nicholson Andrew G AG Cullup Thomas T Jenkins Lucy L Carr Siobhán B SB Aurora Paul P Lemullois Michel M Aubusson-Fleury Anne A Papon Jean-François JF O'Callaghan Christopher C Amselem Serge S Hogg Claire C Escudier Estelle E Tassin Anne-Marie AM Mitchison Hannah M HM
American journal of human genetics 20181121 6
Motile cilia move body fluids and gametes and the beating of cilia lining the airway epithelial surfaces ensures that they are kept clear and protected from inhaled pathogens and consequent respiratory infections. Dynein motor proteins provide mechanical force for cilia beating. Dynein mutations are a common cause of primary ciliary dyskinesia (PCD), an inherited condition characterized by deficient mucociliary clearance and chronic respiratory disease coupled with laterality disturbances and su ...[more]