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N-Heterocyclic Carbenes Derived from Guanosine: Synthesis and Evidences of Their Antiproliferative Activity.

ABSTRACT: Palladium(II) and platinum(II) complexes bearing N-heterocyclic carbenes derived from guanosine are synthesized via oxidative addition, followed by protonation in the presence of acid. Cytotoxicity of the compounds is evaluated in several cell lines. Compounds 2a, 2b, and 3a are selective for glioblastoma U251 cells and are nontoxic toward healthy human embryonic kidney (HEK293) cells.

SUBMITTER: Leitao MIPS 

PROVIDER: S-EPMC6288774 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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N-Heterocyclic Carbenes Derived from Guanosine: Synthesis and Evidences of Their Antiproliferative Activity.

Leitão Maria Inês P S MIPS   Herrera Federico F   Petronilho Ana A  

ACS omega 20181116 11

Palladium(II) and platinum(II) complexes bearing N-heterocyclic carbenes derived from guanosine are synthesized via oxidative addition, followed by protonation in the presence of acid. Cytotoxicity of the compounds is evaluated in several cell lines. Compounds <b>2a</b>, <b>2b</b>, and <b>3a</b> are selective for glioblastoma U251 cells and are nontoxic toward healthy human embryonic kidney (HEK293) cells. ...[more]

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