Ontology highlight
ABSTRACT:
SUBMITTER: Coey AT
PROVIDER: S-EPMC6289658 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Coey Aaron T AT Larsen Kevin P KP Choi Junhong J Barrero Daniel J DJ Puglisi Joseph D JD Puglisi Elisabetta Viani EV
Journal of molecular biology 20180907 24
The initiation of reverse transcription in human immunodeficiency virus-1 is a key early step in the virus replication cycle. During this process, the viral enzyme reverse transcriptase (RT) copies the single-stranded viral RNA (vRNA) genome into double-stranded DNA using human tRNA<sup>Lys</sup><sub>3</sub> as a primer for initiation. The tRNA primer and vRNA genome contain several complementary sequences that are important for regulating reverse transcription initiation kinetics. Using single- ...[more]