Ontology highlight
ABSTRACT:
SUBMITTER: He C
PROVIDER: S-EPMC6289725 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
He Chengyong C Jiang Shengwei S Yao Huan H Zhang Liyin L Yang Chuanli C Jiang Shan S Ruan Fengkai F Zhan Denglin D Liu Gang G Lin Zhongning Z Lin Yuchun Y Chen Xiaoyuan X
Nanomedicine : nanotechnology, biology, and medicine 20180920 1
Mitophagy, a selective autophagy of mitochondria, clears up damaged mitochondria to maintain cell homeostasis. We performed high-content analysis (HCA) to detect the increase of PINK1, an essential protein controlling mitophagy, in hepatic cells treated with several nanoparticles (NPs). PINK1 immunofluorescence-based HCA was more sensitive than assays and detections for cell viability and mitochondrial functions. Of which, superparamagnetic iron oxide (SPIO)-NPs or graphene oxide-quantum dots (G ...[more]