Ontology highlight
ABSTRACT:
SUBMITTER: Chang CN
PROVIDER: S-EPMC6289786 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Chang Chih-Ning CN Singh Arun J AJ Gross Michael K MK Kioussi Chrissa C
Developmental biology 20181108 1
Skeletal muscle is generated by the successive incorporation of primary (embryonic), secondary (fetal), and tertiary (adult) fibers into muscle. Conditional excision of Pitx2 function by an MCK<sup>Cre</sup> driver resulted in animals with histological and ultrastructural defects in P30 muscles and fibers, respectively. Mutant muscle showed severe reduction in mitochondria and FoxO3-mediated mitophagy. Both oxidative and glycolytic energy metabolism were reduced. Conditional excision was limited ...[more]