Ontology highlight
ABSTRACT:
SUBMITTER: Labazi M
PROVIDER: S-EPMC5072523 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Labazi Mohamed M McNeil Anna K AK Kurtz Timothy T Lee Taylor C TC Pegg Ronald B RB Angeli José Pedro Friedmann JPF Conrad Marcus M McNeil Paul L PL
Free radical biology & medicine 20150403
Vitamin E (VE) deficiency results in pronounced muscle weakness and atrophy but the cell biological mechanism of the pathology is unknown. We previously showed that VE supplementation promotes membrane repair in cultured cells and that oxidants potently inhibit repair. Here we provide three independent lines of evidence that VE is required for skeletal muscle myocyte plasma membrane repair in vivo. We also show that when another lipid-directed antioxidant, glutathione peroxidase 4 (Gpx4), is gen ...[more]