Ontology highlight
ABSTRACT:
SUBMITTER: Hinkle JT
PROVIDER: S-EPMC6291234 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Hinkle Jared T JT Perepezko Kate K Mills Kelly A KA Mari Zoltan Z Butala Ankur A Dawson Ted M TM Pantelyat Alexander A Rosenthal Liana S LS Pontone Gregory M GM
Parkinsonism & related disorders 20180822
<h4>Background</h4>Constipation is a prodromal feature of Parkinson's disease (PD) and the gastrointestinal (GI) tract is implicated in the pathogenesis of PD. However, no studies have demonstrated ante-mortem relationships between nigrostriatal dysfunction and GI dysautonomia in PD.<h4>Methods</h4>The Scale for Outcomes in Parkinson's disease for Autonomic Symptoms (SCOPA-AUT) assesses dysautonomia in the multi-center Parkinson's Progression Marker Initiative (PPMI). We used linear mixed-effect ...[more]