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Dopamine transporter availability reflects gastrointestinal dysautonomia in early Parkinson disease.


ABSTRACT: BACKGROUND:Constipation is a prodromal feature of Parkinson's disease (PD) and the gastrointestinal (GI) tract is implicated in the pathogenesis of PD. However, no studies have demonstrated ante-mortem relationships between nigrostriatal dysfunction and GI dysautonomia in PD. METHODS:The Scale for Outcomes in Parkinson's disease for Autonomic Symptoms (SCOPA-AUT) assesses dysautonomia in the multi-center Parkinson's Progression Marker Initiative (PPMI). We used linear mixed-effects models and reliable change indices (RCIs) to examine longitudinal associations between dysautonomia and dopamine transporter (DAT) striatal binding ratios (SBRs) measured by single-photon emission computerized tomography in PPMI participants over four years (n?=?397?at baseline). RESULTS:Adjusted mixed-models of longitudinal data showed that constipation-but not orthostatic hypotension or urinary dysfunction-was associated with reduced SBR in both caudate (P?

SUBMITTER: Hinkle JT 

PROVIDER: S-EPMC6291234 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Dopamine transporter availability reflects gastrointestinal dysautonomia in early Parkinson disease.

Hinkle Jared T JT   Perepezko Kate K   Mills Kelly A KA   Mari Zoltan Z   Butala Ankur A   Dawson Ted M TM   Pantelyat Alexander A   Rosenthal Liana S LS   Pontone Gregory M GM  

Parkinsonism & related disorders 20180822


<h4>Background</h4>Constipation is a prodromal feature of Parkinson's disease (PD) and the gastrointestinal (GI) tract is implicated in the pathogenesis of PD. However, no studies have demonstrated ante-mortem relationships between nigrostriatal dysfunction and GI dysautonomia in PD.<h4>Methods</h4>The Scale for Outcomes in Parkinson's disease for Autonomic Symptoms (SCOPA-AUT) assesses dysautonomia in the multi-center Parkinson's Progression Marker Initiative (PPMI). We used linear mixed-effect  ...[more]

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