Ontology highlight
ABSTRACT:
SUBMITTER: Bardua M
PROVIDER: S-EPMC6291424 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Bardua Markus M Haftmann Claudia C Durek Pawel P Westendorf Kerstin K Buttgereit Antje A Tran Cam Loan CL McGrath Mairi M Weber Melanie M Lehmann Katrin K Addo Richard Kwasi RK Heinz Gitta Anne GA Stittrich Anna-Barbara AB Maschmeyer Patrick P Radbruch Helena H Lohoff Michael M Chang Hyun-Dong HD Radbruch Andreas A Mashreghi Mir-Farzin MF
Frontiers in immunology 20181206
Proinflammatory type 1 T helper (Th1) cells are enriched in inflamed tissues and contribute to the maintenance of chronic inflammation in rheumatic diseases. Here we show that the microRNA- (miR-) 31 is upregulated in murine Th1 cells with a history of repeated reactivation and in memory Th cells isolated from the synovial fluid of patients with rheumatic joint disease. Knock-down of miR-31 resulted in the upregulation of genes associated with cytoskeletal rearrangement and motility and induced ...[more]