Identification of aminosulfonylarylisoxazole as microRNA-31 regulators.
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ABSTRACT:
SUBMITTER: Im K
PROVIDER: S-EPMC5544221 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Identification of aminosulfonylarylisoxazole as microRNA-31 regulators.
Im Kyungtaek K Song Jiho J Han Young Taek YT Lee Seul S Kang Soowon S Hwang Kwang Woo KW Min Hyeyoung H Min Kyung Hoon KH
PloS one 20170804 8
The discovery of small-molecule regulators of microRNAs remains challenging, but a few have been reported. Herein, we describe small-molecule inhibitors of miR-31, a tumor-associated microRNA (miRNA), identified by high-throughput screening using a cell-based reporter assay. Aminosulfonylarylisoxazole compounds exhibited higher specificity for miR-31 than for six other miRNAs, i.e., miR-15a, miR-16, miR-21, miR-92a-1, miR-146a, and miR-155, and increased the expression of miR-31 target genes. Th ...[more]
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