Ontology highlight
ABSTRACT:
SUBMITTER: Yoshino R
PROVIDER: S-EPMC6877583 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Yoshino Ryunosuke R Yasuo Nobuaki N Sekijima Masakazu M
Scientific reports 20191125 1
Baloxavir marboxil (BXM), an antiviral drug for influenza virus, inhibits RNA replication by binding to RNA replication cap-dependent endonuclease (CEN) of influenza A and B viruses. Although this drug was only approved by the FDA in October 2018, drug resistant viruses have already been detected from clinical trials owing to an I38 mutation of CEN. To investigate the reduction of drug sensitivity by the I38 mutant variants, we performed a molecular dynamics (MD) simulation on the CEN-BXM comple ...[more]