Ontology highlight
ABSTRACT:
SUBMITTER: Antonova SV
PROVIDER: S-EPMC6292499 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Antonova Simona V SV Haffke Matthias M Corradini Eleonora E Mikuciunas Mykolas M Low Teck Y TY Signor Luca L van Es Robert M RM Gupta Kapil K Scheer Elisabeth E Vos Harmjan R HR Tora László L Heck Albert J R AJR Timmers H T Marc HTM Berger Imre I
Nature structural & molecular biology 20181203 12
TFIID is a cornerstone of eukaryotic gene regulation. Distinct TFIID complexes with unique subunit compositions exist and several TFIID subunits are shared with other complexes, thereby conveying precise cellular control of subunit allocation and functional assembly of this essential transcription factor. However, the molecular mechanisms that underlie the regulation of TFIID remain poorly understood. Here we use quantitative proteomics to examine TFIID submodules and assembly mechanisms in huma ...[more]