Ontology highlight
ABSTRACT:
SUBMITTER: Cuellar J
PROVIDER: S-EPMC6599039 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Cuéllar Jorge J Ludlam W Grant WG Tensmeyer Nicole C NC Aoba Takuma T Dhavale Madhura M Santiago César C Bueno-Carrasco M Teresa MT Mann Michael J MJ Plimpton Rebecca L RL Makaju Aman A Franklin Sarah S Willardson Barry M BM Valpuesta José M JM
Nature communications 20190628 1
The mechanistic target of rapamycin (mTOR) kinase forms two multi-protein signaling complexes, mTORC1 and mTORC2, which are master regulators of cell growth, metabolism, survival and autophagy. Two of the subunits of these complexes are mLST8 and Raptor, β-propeller proteins that stabilize the mTOR kinase and recruit substrates, respectively. Here we report that the eukaryotic chaperonin CCT plays a key role in mTORC assembly and signaling by folding both mLST8 and Raptor. A high resolution (4.0 ...[more]