Ontology highlight
ABSTRACT:
SUBMITTER: Matsuzawa S
PROVIDER: S-EPMC6292586 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Matsuzawa Shun S Isobe Masaharu M Kurosawa Nobuyuki N
PloS one 20181213 12
The guinea pig has been used as a model to study various human infectious diseases because of its similarity to humans regarding symptoms and immune response, but little is known about the humoral immune response. To better understand the mechanism underlying the generation of the antibody repertoire in guinea pigs, we performed deep sequencing of full-length immunoglobulin variable chains from naïve B and plasma cells. We gathered and analyzed nearly 16,000 full-length VH, Vκ and Vλ genes and a ...[more]