Ontology highlight
ABSTRACT:
SUBMITTER: Brady OA
PROVIDER: S-EPMC6292694 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
eLife 20181206
The transcription factors TFE3 and TFEB cooperate to regulate autophagy induction and lysosome biogenesis in response to starvation. Here we demonstrate that DNA damage activates TFE3 and TFEB in a p53 and mTORC1 dependent manner. RNA-Seq analysis of TFEB/TFE3 double-knockout cells exposed to etoposide reveals a profound dysregulation of the DNA damage response, including upstream regulators and downstream p53 targets. TFE3 and TFEB contribute to sustain p53-dependent response by stabilizing p53 ...[more]