Ontology highlight
ABSTRACT:
SUBMITTER: Kopljar I
PROVIDER: S-EPMC6294263 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Stem cell reports 20181201 6
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have emerged as a promising cardiac safety platform, demonstrated by numerous validation studies using drugs with known cardiac adverse effects in humans. However, the challenge remains to implement hiPSC-CMs into cardiac de-risking of new chemical entities (NCEs) during preclinical drug development. Here, we used the calcium transient screening assay in hiPSC-CMs to develop a hazard score system for cardiac electrical liabil ...[more]