Ontology highlight
ABSTRACT:
SUBMITTER: Mathur A
PROVIDER: S-EPMC4352848 | biostudies-other | 2015 Mar
REPOSITORIES: biostudies-other
Mathur Anurag A Loskill Peter P Shao Kaifeng K Huebsch Nathaniel N Hong SoonGweon S Marcus Sivan G SG Marks Natalie N Mandegar Mohammad M Conklin Bruce R BR Lee Luke P LP Healy Kevin E KE
Scientific reports 20150309
Drug discovery and development are hampered by high failure rates attributed to the reliance on non-human animal models employed during safety and efficacy testing. A fundamental problem in this inefficient process is that non-human animal models cannot adequately represent human biology. Thus, there is an urgent need for high-content in vitro systems that can better predict drug-induced toxicity. Systems that predict cardiotoxicity are of uppermost significance, as approximately one third of sa ...[more]