Ontology highlight
ABSTRACT:
SUBMITTER: Stathias V
PROVIDER: S-EPMC6294341 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Stathias Vasileios V Jermakowicz Anna M AM Maloof Marie E ME Forlin Michele M Walters Winston W Suter Robert K RK Durante Michael A MA Williams Sion L SL Harbour J William JW Volmar Claude-Henry CH Lyons Nicholas J NJ Wahlestedt Claes C Graham Regina M RM Ivan Michael E ME Komotar Ricardo J RJ Sarkaria Jann N JN Subramanian Aravind A Golub Todd R TR Schürer Stephan C SC Ayad Nagi G NG
Nature communications 20181214 1
Glioblastoma (GBM) is the most common primary adult brain tumor. Despite extensive efforts, the median survival for GBM patients is approximately 14 months. GBM therapy could benefit greatly from patient-specific targeted therapies that maximize treatment efficacy. Here we report a platform termed SynergySeq to identify drug combinations for the treatment of GBM by integrating information from The Cancer Genome Atlas (TCGA) and the Library of Integrated Network-Based Cellular Signatures (LINCS). ...[more]