Ontology highlight
ABSTRACT:
SUBMITTER: Noonan AM
PROVIDER: S-EPMC7765376 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Noonan Anne M AM Cousins Amanda A Anderson David D Zeligs Kristen P KP Bunch Kristen K Hernandez Lidia L Shibuya Yusuke Y Goldlust Ian S IS Guha Rajarshi R Ferrer Marc M Thomas Craig J CJ Annunziata Christina M CM
Cancers 20201215 12
Inhibitor of apoptosis (IAP) proteins are frequently upregulated in ovarian cancer, resulting in the evasion of apoptosis and enhanced cellular survival. Birinapant, a synthetic second mitochondrial activator of caspases (SMAC) mimetic, suppresses the functions of IAP proteins in order to enhance apoptotic pathways and facilitate tumor death. Despite on-target activity, however, pre-clinical trials of single-agent birinapant have exhibited minimal activity in the recurrent ovarian cancer setting ...[more]