Ontology highlight
ABSTRACT:
SUBMITTER: Bancells C
PROVIDER: S-EPMC6294672 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Bancells Cristina C Llorà-Batlle Oriol O Poran Asaf A Nötzel Christopher C Rovira-Graells Núria N Elemento Olivier O Kafsack Björn F C BFC Cortés Alfred A
Nature microbiology 20181126 1
Human to vector transmission of malaria requires that some blood-stage parasites abandon asexual growth and convert into non-replicating sexual forms called gametocytes. The initial steps of gametocytogenesis remain largely uncharacterized. Here, we study this part of the malaria life cycle in Plasmodium falciparum using PfAP2-G, the master regulator of sexual conversion, as a marker of commitment. We demonstrate the existence of PfAP2-G-positive sexually committed parasite stages that precede t ...[more]