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Serotonin receptors and suicide, major depression, alcohol use disorder and reported early life adversity.


ABSTRACT: Serotonin neurotransmitter deficits are reported in suicide, major depressive disorder (MDD) and alcohol use disorder (AUD). To compare pathophysiology in these disorders, we mapped brain serotonin transporter (SERT), 5-HT1A, and 5-HT2A receptor binding throughout prefrontal cortex and in anterior cingulate cortex postmortem. Cases and controls died suddenly minimizing agonal effects and had a postmortem interval ?24?h to avoid compromised brain integrity. Neuropathology and toxicology confirmed absence of neuropathology and psychotropic medications. For most subjects (167 of 232), a DSM-IV Axis I diagnosis was made by psychological autopsy. Autoradiography was performed in right hemisphere coronal sections at a pre-genual level. Linear model analyses included sex and age with group and Brodmann area as interaction terms. SERT binding was lower in suicides (p?=?0.004) independent of sex (females?

SUBMITTER: Underwood MD 

PROVIDER: S-EPMC6294796 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Serotonin receptors and suicide, major depression, alcohol use disorder and reported early life adversity.

Underwood Mark D MD   Kassir Suham A SA   Bakalian Mihran J MJ   Galfalvy Hanga H   Dwork Andrew J AJ   Mann J John JJ   Arango Victoria V  

Translational psychiatry 20181214 1


Serotonin neurotransmitter deficits are reported in suicide, major depressive disorder (MDD) and alcohol use disorder (AUD). To compare pathophysiology in these disorders, we mapped brain serotonin transporter (SERT), 5-HT<sub>1A</sub>, and 5-HT<sub>2A</sub> receptor binding throughout prefrontal cortex and in anterior cingulate cortex postmortem. Cases and controls died suddenly minimizing agonal effects and had a postmortem interval ≤24 h to avoid compromised brain integrity. Neuropathology an  ...[more]

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