Ontology highlight
ABSTRACT:
SUBMITTER: Underwood MD
PROVIDER: S-EPMC6294796 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Underwood Mark D MD Kassir Suham A SA Bakalian Mihran J MJ Galfalvy Hanga H Dwork Andrew J AJ Mann J John JJ Arango Victoria V
Translational psychiatry 20181214 1
Serotonin neurotransmitter deficits are reported in suicide, major depressive disorder (MDD) and alcohol use disorder (AUD). To compare pathophysiology in these disorders, we mapped brain serotonin transporter (SERT), 5-HT<sub>1A</sub>, and 5-HT<sub>2A</sub> receptor binding throughout prefrontal cortex and in anterior cingulate cortex postmortem. Cases and controls died suddenly minimizing agonal effects and had a postmortem interval ≤24 h to avoid compromised brain integrity. Neuropathology an ...[more]