Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC6297223 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Zhang Xianglong X Zhang Ying Y Zhu Xiaowei X Purmann Carolin C Haney Michael S MS Ward Thomas T Khechaduri Arineh A Yao Jie J Weissman Sherman M SM Urban Alexander E AE
Nature communications 20181217 1
Large copy number variants (CNVs) in the human genome are strongly associated with common neurodevelopmental, neuropsychiatric disorders such as schizophrenia and autism. Here we report on the epigenomic effects of the prominent large deletion CNVs on chromosome 22q11.2 and on chromosome 1q21.1. We use Hi-C analysis of long-range chromosome interactions, including haplotype-specific Hi-C analysis, ChIP-Seq analysis of regulatory histone marks, and RNA-Seq analysis of gene expression patterns. We ...[more]