Neuronal Receptors Display Cytoskeleton-Independent Directed Motion on the Plasma Membrane.
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ABSTRACT:
SUBMITTER: Taylor RD
PROVIDER: S-EPMC6297241 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
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Neuronal Receptors Display Cytoskeleton-Independent Directed Motion on the Plasma Membrane.
Taylor Ruth D RD Heine Martin M Emptage Nigel J NJ Andreae Laura C LC
iScience 20181205
Directed transport of transmembrane proteins is generally believed to occur via intracellular transport vesicles. However, using single-particle tracking in rat hippocampal neurons with a pH-sensitive quantum dot probe that specifically reports surface movement of receptors, we have identified a subpopulation of neuronal EphB2 receptors that exhibit directed motion between synapses within the plasma membrane itself. This receptor movement occurs independently of the cytoskeleton but is dependent ...[more]
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