Ontology highlight
ABSTRACT:
SUBMITTER: Villa-Alvarez M
PROVIDER: S-EPMC6297751 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Villa-Álvarez Mónica M Sordo-Bahamonde Christian C Lorenzo-Herrero Seila S Gonzalez-Rodriguez Ana P AP Gonzalez-Rodriguez Ana P AP Payer Angel R AR Gonzalez-Garcia Esther E Villa-Álvarez María C MC López-Soto Alejandro A Gonzalez Segundo S
Frontiers in immunology 20181211
One of the cardinal features of chronic lymphocytic leukemia (CLL) is its association with a profound immunosuppression. NK cell function is markedly impaired in CLL patients, who show a significant dysregulation of the expression of activating and inhibitory receptors. Here, we analyzed the role of the novel inhibitory receptor Ig-like transcript 2 (ILT2, also termed LIR-1, LILRB1) in the regulation of NK cells in CLL. Our results show that ILT2 expression was significantly decreased on leukemi ...[more]