Ontology highlight
ABSTRACT:
SUBMITTER: Kim H
PROVIDER: S-EPMC6298040 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Cell 20181201 7
Irisin is secreted by muscle, increases with exercise, and mediates certain favorable effects of physical activity. In particular, irisin has been shown to have beneficial effects in adipose tissues, brain, and bone. However, the skeletal response to exercise is less clear, and the receptor for irisin has not been identified. Here we show that irisin binds to proteins of the αV class of integrins, and biophysical studies identify interacting surfaces between irisin and αV/β5 integrin. Chemical i ...[more]