Irisin Mediates Effects on Bone and Fat via ?V Integrin Receptors.
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ABSTRACT:
SUBMITTER: Kim H
PROVIDER: S-EPMC6298040 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.
Kim Hyeonwoo H Wrann Christiane D CD Jedrychowski Mark M Vidoni Sara S Kitase Yukiko Y Nagano Kenichi K Zhou Chenhe C Chou Joshua J Parkman Virginia-Jeni A VA Novick Scott J SJ Strutzenberg Timothy S TS Pascal Bruce D BD Le Phuong T PT Brooks Daniel J DJ Roche Alexander M AM Gerber Kaitlyn K KK Mattheis Laura L Chen Wenjing W Tu Hua H Bouxsein Mary L ML Griffin Patrick R PR Baron Roland R Rosen Clifford J CJ Bonewald Lynda F LF Spiegelman Bruce M BM
Cell 20181201 7
Irisin is secreted by muscle, increases with exercise, and mediates certain favorable effects of physical activity. In particular, irisin has been shown to have beneficial effects in adipose tissues, brain, and bone. However, the skeletal response to exercise is less clear, and the receptor for irisin has not been identified. Here we show that irisin binds to proteins of the αV class of integrins, and biophysical studies identify interacting surfaces between irisin and αV/β5 integrin. Chemical i ...[more]
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