Dataset Information

Reduced Prevalence and Incidence of Cognitive Impairment Among Centenarian Offspring.

ABSTRACT:

Background

Centenarian offspring have better health and lower mortality in comparison to referent cohorts, however it is unknown whether they have preserved cognition at older ages.

Methods

This prospective study of 491 centenarian offspring and 270 referent participants without familial longevity (mean baseline age 75.5 years) from the New England Centenarian Study analyzed longitudinal cognitive assessments performed using the Telephone Interview for Cognitive Status. Logistic regression was used for cognitive impairment at baseline and Cox proportional hazards regression for risk of incident cognitive impairment.

Results

After adjustment for age, sex, education, stroke, and diabetes, offspring were 46% less likely to have baseline cognitive impairment (adjusted odds ratio 0.54, 95% CI 0.35-0.82) and were 27% less likely to become cognitively impaired over a median follow-up of 7.8 years (adjusted hazard ratio 0.73, 95% CI 0.53-0.99). Female gender was also independently associated with lower odds of baseline cognitive impairment and lower risk of incident cognitive impairment.

Conclusions

Familial longevity may confer exposure to genetic and environmental factors that predispose centenarian offspring to preservation of cognitive function at older ages. Centenarian offspring cohorts may provide an opportunity to study cognitive resilience associated with familial longevity.

SUBMITTER: Andersen SL

PROVIDER: S-EPMC6298187 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Publications

Reduced Prevalence and Incidence of Cognitive Impairment Among Centenarian Offspring.

Andersen Stacy L SL Sweigart Benjamin B Sebastiani Paola P Drury Julia J Sidlowski Sara S Perls Thomas T TT

The journals of gerontology. Series A, Biological sciences and medical sciences 20190101 1

<h4>Background</h4>Centenarian offspring have better health and lower mortality in comparison to referent cohorts, however it is unknown whether they have preserved cognition at older ages.<h4>Methods</h4>This prospective study of 491 centenarian offspring and 270 referent participants without familial longevity (mean baseline age 75.5 years) from the New England Centenarian Study analyzed longitudinal cognitive assessments performed using the Telephone Interview for Cognitive Status. Logistic r ...[more]

PMID: 29931286

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Project description:IMPORTANCE:Family studies of centenarians and long-lived persons have found substantial familial aggregation of survival to extreme ages; however, the extent to which such familial longevity is characterized by cognitively intact survival is not established. OBJECTIVE:To determine whether families with exceptional longevity are protected against cognitive impairment consistent with Alzheimer disease. DESIGN:Cross-sectional analysis. SETTING:Multisite study in New York, Massachusetts, Pennsylvania, and Denmark. PARTICIPANTS:A total of 1870 individuals (1510 family members and 360 spouse controls) recruited through the Long Life Family Study. MAIN OUTCOME AND MEASURE:Prevalence of cognitive impairment based on a diagnostic algorithm validated using the National Alzheimer's Coordinating Center data set. RESULTS:The cognitive algorithm classified 546 individuals (38.5%) as having cognitive impairment consistent with Alzheimer disease. Long Life Family Study probands had a slightly but not statistically significant reduced risk of cognitive impairment compared with spouse controls (121 of 232 for probands vs 45 of 103 for spouse controls; odds ratio?=?0.7; 95% CI, 0.4-1.4), whereas Long Life Family Study sons and daughters had a clearly reduced risk of cognitive impairment (11 of 213 for sons and daughters vs 28 of 216 for spouse controls; odds ratio?=?0.4; 95% CI, 0.2-0.9). Restriction to nieces and nephews in the offspring generation attenuated this effect (37 of 328 for nieces and nephews vs 28 of 216 for spouse controls; odds ratio?=?0.8; 95% CI, 0.4-1.4). CONCLUSIONS AND RELEVANCE:Rates of cognitive impairment characteristic of Alzheimer disease were relatively high. In the proband generation, rates were comparable across family members and spouse controls, whereas sons and daughters of probands had significantly lower rates than spouse controls. Results suggest a delayed onset of cognitive impairment in families with exceptional longevity, but assessment of age-specific incidence rates is required to confirm this hypothesis.

Project description:BackgroundCognitive impairment seems to be frequent in intracerebral hemorrhage (ICH) survivors, but remains widely understudied. In this study, we investigated the frequency and patterns of vascular cognitive disorders (VCDs) in patients with cerebral amyloid angiopathy (CAA)-related and deep ICH compared to patients with mild cognitive impairment due to Alzheimer's disease (MCI-AD) and healthy controls.MethodsWe prospectively recruited 20 patients with CAA-related lobar ICH, 20 with deep ICH, 20 with MCI-AD and 17 healthy controls. Patients with cognitive decline pre-ICH were excluded from the analysis. Each participant underwent a comprehensive neuropsychological assessment and a structural brain MRI. Cognitive assessment was performed at a median delay of 4 months after the acute phase in ICH patients, and more than 6 months after the first complaint in MCI-AD patients. Cognitive profiles were compared between groups. The prevalence of VCDs in the ICH groups was estimated using the recent VASCOG criteria.Results"Mild" and "major VCDs" were respectively observed in 87.5% and 2.5% of all ICH patients. Every patient in the CAA group had mild VCDs. No significant difference was observed in cognitive functioning between CAA-related and deep ICH patients. The most impaired process in the CAA group was naming, with a mean (±standard deviation) z-score of -5.2 ±5.5, followed by processing speed (-4.1±3.3), executive functioning (-2.6 ±2.5), memory (-2.4 ±3.5) and attention (-0.9 ±1.3). This cognitive pattern was different from the MCI-AD patients, but the groups were only different in gestural praxis, and by construction, in memory processes.ConclusionsVCDs are frequent after ICH. Cognitive patterns of patients with deep or CAA-related ICH did not differ, but there was impaired performance in specific domains distinct from the effects of Alzheimer's disease.Clinical trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01619709.

Dataset Information

Reduced Prevalence and Incidence of Cognitive Impairment Among Centenarian Offspring.

Background

Methods

Results

Conclusions

Publications

Reduced Prevalence and Incidence of Cognitive Impairment Among Centenarian Offspring.

Similar Datasets

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