Ontology highlight
ABSTRACT:
SUBMITTER: Yang J
PROVIDER: S-EPMC6298415 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Yang Junbao J Jing Lichen L James Eddie A EA Gebe John A JA Koelle David M DM Kwok William W WW
Frontiers in immunology 20181203
Infection and vaccination can lead to activation of autoreactive T cells, including the activation of cross-reactive T cells. However, detecting these cross-reactive T cells and identifying the non-self and self-antigen epitopes is difficult. The current study demonstrates the utility of a novel approach that effectively accomplishes both. We utilized surface expression of CD38 on newly activated CD4 memory T cells as a strategy to identify type 1 diabetes associated autoreactive T cells activat ...[more]