Unknown

Dataset Information

0

Continuously Updated Estimation of Heart Transplant Waitlist Mortality.


ABSTRACT: BACKGROUND:Heart transplant allocation in the United States is made on the basis of coarse tiers, defined by mechanical circulatory devices and therapy for advanced heart failure, updated infrequently as a patient's condition deteriorates. Thus, many patients die awaiting heart transplantation. What is needed is a tool that continuously updates risk of mortality as a patient's condition changes to inform clinical decision making. OBJECTIVES:This study sought to develop a decision aid that aggregates adverse events and measures of end-organ function into a continuously updated waitlist mortality estimate. METHODS:From 2008 to 2013, 414 patients were listed for heart transplantation at Cleveland Clinic, Cleveland, Ohio. The endpoint was waitlist death. Pre-listing patient characteristics and events and laboratory results during listing were analyzed. At each event or measurement change, mortality was recomputed from the resulting model. RESULTS:There were 77 waitlist deaths, with 1- and 4-year survival of 85% and 57%, respectively. When time-varying events and measurements were incorporated into a mortality model, pre-listing patient characteristics became nonsignificant. Neurological events (hazard ratio [HR]: 13.5; 95% confidence interval [CI]: 7.63 to 23.8), new requirement for dialysis (HR: 3.67; 95% CI: 1.88 to 7.14), more respiratory complications (HR: 1.79 per episode; 95% CI: 1.23 to 2.59), and higher serum bilirubin (p < 0.0001) and creatinine (p < 0.0001) yielded continuously updated estimates of patient-specific mortality across the waitlist period. CONCLUSIONS:Mortality risk for patients with advanced heart failure who are listed for transplantation is related to adverse events and end-organ dysfunction that change over time. A continuously updated mortality estimate, combined with clinical evaluation, may inform status changes that could reduce mortality on the heart transplant waiting list.

SUBMITTER: Blackstone EH 

PROVIDER: S-EPMC6298792 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications

Continuously Updated Estimation of Heart Transplant Waitlist Mortality.

Blackstone Eugene H EH   Rajeswaran Jeevanantham J   Cruz Vincent B VB   Hsich Eileen M EM   Koprivanac Marijan M   Smedira Nicholas G NG   Hoercher Katherine J KJ   Thuita Lucy L   Starling Randall C RC  

Journal of the American College of Cardiology 20180801 6


<h4>Background</h4>Heart transplant allocation in the United States is made on the basis of coarse tiers, defined by mechanical circulatory devices and therapy for advanced heart failure, updated infrequently as a patient's condition deteriorates. Thus, many patients die awaiting heart transplantation. What is needed is a tool that continuously updates risk of mortality as a patient's condition changes to inform clinical decision making.<h4>Objectives</h4>This study sought to develop a decision  ...[more]

Similar Datasets

| S-EPMC7160742 | biostudies-literature
| S-EPMC6591021 | biostudies-literature
| S-EPMC6836691 | biostudies-literature
| S-EPMC5912344 | biostudies-other
| S-EPMC4892941 | biostudies-literature
| S-EPMC7726636 | biostudies-literature
| S-EPMC6482090 | biostudies-literature
| S-EPMC8601542 | biostudies-literature
| S-EPMC9320797 | biostudies-literature
| S-EPMC9285771 | biostudies-literature