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Dietary geraniol ameliorates intestinal dysbiosis and relieves symptoms in irritable bowel syndrome patients: a pilot study.


ABSTRACT: BACKGROUND:(Trans)-3,7-Dimethyl-2,6-octadien-1-ol, commonly called geraniol (Ge-OH), is an acyclic monoterpene alcohol with well-known anti-inflammatory and antimicrobial properties. Ge-OH is a non-toxic compound classified as Generally Recognized As Safe (GRAS) by the US Food and Drug Administration and the European Food Security Agency. METHODS:Ge-OH was orally administered at a maximum daily dose of 8?mg?kg(-?1) body weight for four weeks in a delayed release formulation capable of reaching the colon. Fecal microbiota and blood cytokines were analyzed before and after Ge-OH treatment, as well as IBS symptomatology by using Visual Analogue Scale (VAS-IBS). RESULTS:The results show that orally administered Ge-OH is a powerful modulator of the intestinal microbial ecosystem, capable of leading to increased relative abundances of Collinsella and especially Faecalibacterium, a well-known health-promoting butyrate producer consistently found to be decreased in IBS patients. Moreover, Ge-OH strongly improved the clinical symptoms of colitis by significantly reducing the score recorded by the VAS-IBS questionnaire. Clinical improvement was associated with a significant reduction in the circulating MIP-1?, a chemokine found to be increased in several IBS patients. CONCLUSION:Ge-OH could be a powerful component for food supplement targeted to the treatment of IBS patients. TRIAL REGISTRATION:ISRCTN47041881 , retrospectively registered on 19th July 2018.

SUBMITTER: Rizzello F 

PROVIDER: S-EPMC6299992 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Dietary geraniol ameliorates intestinal dysbiosis and relieves symptoms in irritable bowel syndrome patients: a pilot study.

Rizzello Fernando F   Ricci Chiara C   Scandella Michela M   Cavazza Elena E   Giovanardi Elisabetta E   Valerii Maria Chiara MC   Campieri Massimo M   Comparone Antonietta A   De Fazio Luigia L   Candela Marco M   Turroni Silvia S   Spisni Enzo E  

BMC complementary and alternative medicine 20181219 1


<h4>Background</h4>(Trans)-3,7-Dimethyl-2,6-octadien-1-ol, commonly called geraniol (Ge-OH), is an acyclic monoterpene alcohol with well-known anti-inflammatory and antimicrobial properties. Ge-OH is a non-toxic compound classified as Generally Recognized As Safe (GRAS) by the US Food and Drug Administration and the European Food Security Agency.<h4>Methods</h4>Ge-OH was orally administered at a maximum daily dose of 8 mg kg<sup>(- 1)</sup> body weight for four weeks in a delayed release formula  ...[more]

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