Kappa Opioid Receptor Distribution and Function in Primary Afferents.
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ABSTRACT:
SUBMITTER: Snyder LM
PROVIDER: S-EPMC6300132 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
Kappa Opioid Receptor Distribution and Function in Primary Afferents.
Snyder Lindsey M LM Chiang Michael C MC Loeza-Alcocer Emanuel E Omori Yu Y Hachisuka Junichi J Sheahan Tayler D TD Gale Jenna R JR Adelman Peter C PC Sypek Elizabeth I EI Fulton Stephanie A SA Friedman Robert L RL Wright Margaret C MC Duque Melissa Giraldo MG Lee Yeon Sun YS Hu Zeyu Z Huang Huizhen H Cai Xiaoyun X Meerschaert Kimberly A KA Nagarajan Vidhya V Hirai Toshiro T Scherrer Gregory G Kaplan Daniel H DH Porreca Frank F Davis Brian M BM Gold Michael S MS Koerber H Richard HR Ross Sarah E SE
Neuron 20180901 6
Primary afferents are known to be inhibited by kappa opioid receptor (KOR) signaling. However, the specific types of somatosensory neurons that express KOR remain unclear. Here, using a newly developed KOR-cre knockin allele, viral tracing, single-cell RT-PCR, and ex vivo recordings, we show that KOR is expressed in several populations of primary afferents: a subset of peptidergic sensory neurons, as well as low-threshold mechanoreceptors that form lanceolate or circumferential endings around ha ...[more]
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