Ontology highlight
ABSTRACT:
SUBMITTER: Journey SN
PROVIDER: S-EPMC6301200 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Journey Sara N SN Alden Stephanie L SL Hewitt Will M WM Peach Megan L ML Nicklaus Marc C MC Schneekloth John S JS
MedChemComm 20181005 12
Non-B DNA structures represent intriguing and challenging targets for small molecules. For example, the promoter of the <i>HRAS</i> oncogene contains multiple G-quadruplex and i-motif structures, atypical globular folds that serve as molecular switches for gene expression. Of the two, i-motif structures are far less studied. Here, we report the first example of small organic compounds that directly interact with the <i>hras</i>-1<sup>Y</sup> i-motif. We use a small molecule microarray screen to ...[more]