Dataset Information

Active Fovea-Based Vision Through Computationally-Effective Model-Based Prediction.

ABSTRACT: What motivates an action in the absence of a definite reward? Taking the case of visuomotor control, we consider a minimal control problem that is how select the next saccade, in a sequence of discrete eye movements, when the final objective is to better interpret the current visual scene. The visual scene is modeled here as a partially-observed environment, with a generative model explaining how the visual data is shaped by action. This allows to interpret different action selection metrics proposed in the literature, including the Salience, the Infomax and the Variational Free Energy, under a single information theoretic construct, namely the view-based Information Gain. Pursuing this analytic track, two original action selection metrics named the Information Gain Lower Bound (IGLB) and the Information Gain Upper Bound (IGUB) are then proposed. Showing either a conservative or an optimistic bias regarding the Information Gain, they strongly simplify its calculation. An original fovea-based visual scene decoding setup is then proposed, with numerical experiments highlighting different facets of artificial fovea-based vision. A first and principal result is that state-of-the-art recognition rates are obtained with fovea-based saccadic exploration, using less than 10% of the original image's data. Those satisfactory results illustrate the advantage of mixing predictive control with accurate state-of-the-art predictors, namely a deep neural network. A second result is the sub-optimality of some classical action-selection metrics widely used in the literature, that is not manifest with finely-tuned inference models, but becomes patent when coarse or faulty models are used. Last, a computationally-effective predictive model is developed using the IGLB objective, with pre-processed visual scan-path read-out from memory, bypassing computationally-demanding predictive calculations. This last simplified setting is shown effective in our case, showing both a competing accuracy and a good robustness to model flaws.

SUBMITTER: Dauce E

PROVIDER: S-EPMC6302111 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Publications

Active Fovea-Based Vision Through Computationally-Effective Model-Based Prediction.

Daucé Emmanuel E

Frontiers in neurorobotics 20181214

What motivates an action in the absence of a definite reward? Taking the case of visuomotor control, we consider a minimal control problem that is how select the next saccade, in a sequence of discrete eye movements, when the final objective is to better interpret the current visual scene. The visual scene is modeled here as a partially-observed environment, with a generative model explaining how the visual data is shaped by action. This allows to interpret different action selection metrics pro ...[more]

PMID: 30618705

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Project description:In the recent few years, an increasing number of studies have shown that microRNAs (miRNAs) play critical roles in many fundamental and important biological processes. As one of pathogenetic factors, the molecular mechanisms underlying human complex diseases still have not been completely understood from the perspective of miRNA. Predicting potential miRNA-disease associations makes important contributions to understanding the pathogenesis of diseases, developing new drugs, and formulating individualized diagnosis and treatment for diverse human complex diseases. Instead of only depending on expensive and time-consuming biological experiments, computational prediction models are effective by predicting potential miRNA-disease associations, prioritizing candidate miRNAs for the investigated diseases, and selecting those miRNAs with higher association probabilities for further experimental validation. In this study, Path-Based MiRNA-Disease Association (PBMDA) prediction model was proposed by integrating known human miRNA-disease associations, miRNA functional similarity, disease semantic similarity, and Gaussian interaction profile kernel similarity for miRNAs and diseases. This model constructed a heterogeneous graph consisting of three interlinked sub-graphs and further adopted depth-first search algorithm to infer potential miRNA-disease associations. As a result, PBMDA achieved reliable performance in the frameworks of both local and global LOOCV (AUCs of 0.8341 and 0.9169, respectively) and 5-fold cross validation (average AUC of 0.9172). In the cases studies of three important human diseases, 88% (Esophageal Neoplasms), 88% (Kidney Neoplasms) and 90% (Colon Neoplasms) of top-50 predicted miRNAs have been manually confirmed by previous experimental reports from literatures. Through the comparison performance between PBMDA and other previous models in case studies, the reliable performance also demonstrates that PBMDA could serve as a powerful computational tool to accelerate the identification of disease-miRNA associations.

Dataset Information

Active Fovea-Based Vision Through Computationally-Effective Model-Based Prediction.

Publications

Active Fovea-Based Vision Through Computationally-Effective Model-Based Prediction.

Similar Datasets

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